Hemodynamic, Autonomic, and Vascular Effects of Exposure to Coarse Particulate Matter Air Pollution from a Rural Location
نویسندگان
چکیده
BACKGROUND Fine particulate matter (PM) air pollution is associated with numerous adverse health effects, including increased blood pressure (BP) and vascular dysfunction. Coarse PM substantially contributes to global air pollution, yet differs in characteristics from fine particles and is currently not regulated. However, the cardiovascular (CV) impacts of coarse PM exposure remain largely unknown. OBJECTIVES Our goal was to elucidate whether coarse PM, like fine PM, is itself capable of eliciting adverse CV responses. METHODS We performed a randomized double-blind crossover study in which 32 healthy adults (25.9 ± 6.6 years of age) were exposed to concentrated ambient coarse particles (CAP; 76.2 ± 51.5 μg/m(3)) in a rural location and filtered air (FA) for 2 hr. We measured CV outcomes during, immediately after, and 2 hr postexposures. RESULTS Both systolic (mean difference = 0.32 mmHg; 95% CI: 0.05, 0.58; p = 0.021) and diastolic BP (0.27 mmHg; 95% CI: 0.003, 0.53; p = 0.05) linearly increased per 10 min of exposure during the inhalation of coarse CAP when compared with changes during FA exposure. Heart rate was on average higher (4.1 bpm; 95% CI: 3.06, 5.12; p < 0.0001) and the ratio of low-to-high frequency heart rate variability increased (0.24; 95% CI: 0.07, 0.41; p = 0.007) during coarse particle versus FA exposure. Other outcomes (brachial flow-mediated dilatation, microvascular reactive hyperemia index, aortic hemodynamics, pulse wave velocity) were not differentially altered by the exposures. CONCLUSIONS Inhalation of coarse PM from a rural location is associated with a rapid elevation in BP and heart rate during exposure, likely due to the triggering of autonomic imbalance. These findings add mechanistic evidence supporting the biological plausibility that coarse particles could contribute to the triggering of acute CV events.
منابع مشابه
Air Pollution and Blood Pressure Insights Into the Mechanisms and Mediators of the Effects of Air Pollution Exposure on Blood Pressure and Vascular Function in Healthy Humans
Fine particulate matter air pollution plus ozone impairs vascular function and raises diastolic blood pressure. We aimed to determine the mechanism and air pollutant responsible. The effects of pollution on heart rate variability, blood pressure, biomarkers, and brachial flow-mediated dilatation were determined in 2 randomized, double-blind, crossover studies. In Ann Arbor, 50 subjects were exp...
متن کاملPmn-18: The Effect of Ambient Air Pollution on Infertility
Development disorders may be arisen from the unavoidable maternal exposure to particulate air pollution during the prenatal life that can be affected not only periconceptional period but also postnatal life. A kind of chemical material categorized as air pollutants are present in the urine, blood and semen of exposed men and may decline sperm count and affect sperm quality. Environment toxic ca...
متن کاملEstimating the acute health effects of coarse particulate matter accounting for exposure measurement error.
In air pollution epidemiology, there is a growing interest in estimating the health effects of coarse particulate matter (PM) with aerodynamic diameter between 2.5 and 10 μm. Coarse PM concentrations can exhibit considerable spatial heterogeneity because the particles travel shorter distances and do not remain suspended in the atmosphere for an extended period of time. In this paper, we develop...
متن کاملAssociation of Heart Rate Variability in Taxi Drivers with Marked Changes in Particulate Air Pollution in Beijing in 2008
BACKGROUND Heart rate variability (HRV), a marker of cardiac autonomic function, has been -associated with particulate matter (PM) air pollution, especially in older patients and those with cardio-vascular diseases. However, the effect of PM exposure on cardiac autonomic function in young, healthy adults has received less attention. OBJECTIVES We evaluated the relationship between exposure to...
متن کاملParticulate matter effects on peritoneal macrophages inflammatory function in C57BL/6 mice
Abstract Background: Urban air pollution represents a challenge in Tehran. Health care organs and physicians pay much attention because of health effect on mankind. Nowadays, a majority of air pollution related articles focus on particulate matter adverse effects on human health. Epidemiologic studies show the direct correlation between ambient particulate matter and risk of respiratory sys...
متن کامل